Supporting Information

The RECALDENTTM(CPP-ACP) technology has been extensively researched by staff at the University of Melbourne Dental School since the 1980s.

Journal of Dental Research®

Reynolds EC. The prevention of sub-surface demineralization of bovine enamel and change in plaque composition by casein in an intra-oral model.J Dent Res. 1987; 66: 1120-1127.

Reynolds EC, Cain CJ, Webber FL, Black CL, Riley PF, Johnson IH, et al. Anticariogenicity of calcium phosphate complexes of tryptic casein phosphopeptides in the rat. J Dent Res. 1995;74

Reynolds EC. Remineralization of enamel subsurface lesions by casein phosphopeptide-stabilized calcium phosphate solutions. J Dent Res. 1997;76(9):1587–95.

Reynolds EC. Anticariogenic complexes of amorphous calcium phosphate stabilized by casein phosphopeptides: a review. Spec Care Dentist. 1998;18(1):8–16.

Shen P, Cai F, Nowicki A, Vincent J, Reynolds EC. Remineralization of enamel subsurface lesions by sugar-free chewing gum containing casein phosphopeptide-amorphous calcium phosphate. J Dent Res. 2001;80(12):2066–70.

Reynolds EC, Cai F, Shen P, Walker GD. Retention in plaque and remineralization of enamel lesions by various forms of calcium in a mouthrinse or sugar-free chewing gum. J Dent Res. 2003;82(3):206–11.

Mazzaoui SA, Burrow MF, Tyas MJ, Dashper SG, Eakins D, Reynolds EC. Incorporation of casein phosphopeptide-amorphous calcium phosphate into a glass-ionomer cement. J. Dent. Res. 2003; 82: 914-918.

Reynolds EC, Cai F, Cochrane NJ, Shen P, Walker GD, Morgan MV, et al. Fluoride and casein phosphopeptide-amorphous calcium phosphate. J Dent Res. 2008;87(4):344–8.

Manton DJ, Walker GD, Cai F, Cochrane NJ, Shen P, Reynolds EC. Remineralization of enamel subsurface lesions in situ by the use of three commercially available sugar-free gums. Int J Paediatr Dent. 2008;18(4):284–90.

Noorjahan Laila Huq, Helen Myroforidis, Keith J. Cross, David P. Stanton, Paul D. Veith, Brent R. Ward and Eric C. Reynolds. The Interactions of CPP–ACP with Saliva. Int. J. Mol. Sci. 2016, 17: 915.

American Academy of Pediatric Dentistry

Ramalingam L, Messer LB, Reynolds EC. Adding Casein Phosphopeptide-amorphous Calcium
Phosphate to Sports Drinks to Eliminate In Vitro Erosion. Pediatric Dentistry 2005;27:61-67

Scientific Studies

Reynolds EC. Anticariogenic complexes of amorphous calcium phosphate stabilized by casein phosphopeptides: a review. J Spec Care 1998; 18(1): 8-16.

Iijima Y, Cai F, Shen P, Walker G, Reynolds C, Reynolds EC. Acid resistance of enamel subsurface lesions remineralized by a sugar-free chewing gum containing casein phosphopeptideamorphous calcium phosphate. Caries Res. 2004;38(6):551–6.

Morgan MV, Adams GG, Bailey DL, Tsao CE, Fischman SL, Reynolds EC. The anticariogenic effect of sugar-free gum containing CPPACP nanocomplexes on approximal caries determined using digital bitewing radiography. Caries Res. 2008;42(3):171–84.

Walker GD, Cai F, Shen P, Bailey DL, Yuan Y, Cochrane NJ, Reynolds C, Reynolds EC. Consumption of milk with added casein phosphopeptide-amorphous calcium phosphate remineralizes enamel subsurface lesions in situ. Aust Dent J 2009; 54(3): 245-249

Manton DJ, Cai F, Yuan Y, Walker GD, Cochrane NJ , Reynolds C, Brearley-Messer LJ, Reynolds EC. Effect of casein phosphopeptide-amorphous calcium phosphate added to acidic beverages on enamel erosion in vitro. Aust Dent J 2010; 55: 275–279

Cochrane NJ, Cai F, Huq NL, Burrow MF, Reynolds EC. New approaches to enhanced remineralization of tooth enamel. J Dent. Res. 2010; 89(11): 1187–1197

Cochrane NJ, Reynolds EC. Calcium phosphopeptides - mechanisms of action and evidence for clinical efficacy. Adv Dent Res. 2012;24(2):41–47.

Shen P, Bagheri R, Walker GD, Yuan Y, Stanton DP, Reynolds C, Reynolds EC. Effect of calcium phosphate addition to fluoride containingdental varnishes on enamel demineralization. ust Dent J 2016; 61: 357–365

M. A. ROBERTSON, C. H. KAU, J. D. ENGLISH, R. P. LEE, P. JOHN, J. T. NGUYEN (2011). MI Paste Plus to prevent demineralization in orthodontic patients: A prospective randomized controlled trial. Am J Orthod Dentofacial Orthop 140:660-668.

T. PERIC, D. MARKOVIC, B. PETROVIC, V. RADOJEVIC, T. TODOROVIC, B.A. RADICEVIC, R.J. HEINEMANN, G. SUSIC, A.P. POPADIC, V.T. SPIRIC (2015). Efficacy of pastes containing CPP-ACP and CPP-ACFP in patients with Sjögren’s syndrome. Clin Oral Investig 19(9):2153-2165.

R.K. ROSE (2000). Binding characteristics of Streptococcus mutans for calcium and casein phosphopeptide. Caries Res 34(5):427-431.

R.K. ROSE (2000). Effects of an anti-cariogenic casein phosphopeptide on calcium diffusion in streptococcal model dental plaques. Arch Oral Biol 45(7):569-575.

C. RAHIOTIS, G. VOUGIOUKLAKIS (2007). Effect of a CPP-ACP agent on the demineralization and remineralisation of dentine in vitro. J Dent 35(8):695-698.

C. RAHIOTIS, G. VOUGIOUKLAKIS, G. ELIADES (2008). Characterization of oral films formed in the presence of a CPPACP agent: An in situ study. J Dent 36:272-280.

P.C. CARUANA, S.A. MULAIFY, R. MOAZZEZ, D. BARTLETT (2009). The effect of casein and calcium containing paste on plaque pH following a subsequent carbohydrate challenge. J Dent 37(7):522-526.

M. CECI, M. MIRANDO, R. BELTRAMI, M. CHIESA, C. POGGIO (2015). Protective effect of casein phosphopeptide-amorphous calcium phosphate on enamel erosion: Atomic force microscopy studies. Scanning 37(5):327-334

S. RANJITKAR, J.A. KAIDONIS, L.C. RICHARDS, G.C. TOWNSEND (2009a). The effect of CPP-ACP on enamel wear under severe erosive conditions. Arch Oral Biol 54(6):527-532.

S. RANJITKAR, K.M. RODRIGUEZ, J.A. KAIDONIS, L.C. RICHARDS, G.C. TOWNSEND, D.W. BARTLETT (2009b). The effect of CPP- ACP on erosive enamel and dentine wear by toothbrush abrasion. J Dent 37(4):250-254.

F.A. CROMBIE, N.J. COCHRANE, D.J. MANTON, J.E.A. PALAMARA, E.C. REYNOLDS (2013). Mineralisation of developmentally hypomineralised human enamel in vitro. Caries Res 47:259-263.

C. BARONI, S. MARCHIONNI (2011). MIH supplementation strategies: prospective clinical and laboratory trial. J Dent Res. 90(3):371-6.